Back Cover: Deracemization of Secondary Alcohols by using a Single Alcohol Dehydrogenase (ChemCatChem 8/2016)
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چکیده
منابع مشابه
Reversible Oxidation of Cyclic Secondary Alcohols by Liver Alcohol Dehydrogenase
During a study of cyclic alcohol oxidation by a partially purified rat liver enzyme system (l), it was noted that ethanol was also oxidized by this preparation. Since the ratio of the rate of ethanol oxidation to the rate of cyclohexanol oxidation remained constant during purification, the possibility arose that the activity with cyclic substrates was due to the conventional alcohol dehydrogena...
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An enantioselective asymmetric reduction of phenyl ring-containing prochiral ketones toyield the corresponding optically active secondary alcohols was achieved with W110Asecondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus (W110A TeSADH) inTris-HCl buffer using 2-propanol (30%, v/v) as cosolvent and cosubstrate. This concentration of2-propanol was crucial not only...
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The human liver alpha alpha alcohol dehydrogenase exhibits a different substrate specificity and stereospecificity for secondary alcohols than the human beta 1 beta 1, and gamma 1 gamma 1 or horse liver alcohol dehydrogenases. All of the enzymes efficiently oxidize primary alcohols, but alpha alpha oxidizes secondary alcohols far more efficiently than human beta 1 beta 1 and gamma 1 gamma 1 or ...
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A novel thermostable alcohol dehydrogenase (ADH) showing activity toward aromatic secondary alcohols was identified from the hyperthermophilic archaeon Thermococcus kodakarensis KOD1 (TkADH). The gene, tk0845, which encodes an aldo-keto reductase, was heterologously expressed in Escherichia coli. The enzyme was found to be a monomer with a molecular mass of 31 kDa. It was highly thermostable wi...
متن کاملThe kinetics and mechanism of liver alcohol dehydrogenase with primary and secondary alcohols as substrates.
1. The activity of liver alcohol dehydrogenase with propan-2-ol and butan-2-ol has been confirmed. The activity with the corresponding ketones is small. Initial-rate parameters are reported for the oxidation of these secondary alcohols, and of propan-1-ol and 2-methylpropan-1-ol, and for the reduction of propionaldehyde and 2-methylpropionaldehyde. Substrate inhibition with primary alcohols is ...
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ژورنال
عنوان ژورنال: ChemCatChem
سال: 2016
ISSN: 1867-3880
DOI: 10.1002/cctc.201600404